Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria
Stephen J Rogerson, Rushika S Wijesinghe, Steven R Meshnick
LANCET INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2010
Host immunity is an important but poorly understood determinant of antimalarial efficacy, influencing the outcome of prevention and treatment trials. Variations in host immunity might explain why factors such as host genetics, age, pregnancy, infection with HIV, parasite density, and malaria transmission intensity, can raise or lower apparent cure rates. Recently, attempts have been made to characterise immunological correlates of treatment outcome in Plasmodium falciparum malaria, but not yet for Plasmodium vivax. A better understanding of such correlates might improve trials of antimalarial drugs and provide leads for vaccine development. Greater understanding of the relation between host ..View full abstract
SJR is supported by the National Health and Medical Research Council and the Malaria in Pregnancy Consortium. SRM is supported by the National Institutes of Health and the Malaria in Pregnancy Consortium.