LPA receptor expression in the central nervous system in health and following injury
Yona Goldshmit, Kathryn Munro, Soo Yuen Leong, Alice Pebay, Ann M Turnley
Cell and Tissue Research | SPRINGER | Published : 2010
Lysophosphatidic acid (LPA) is released from platelets following injury and also plays a role in neural development but little is known about its effects in the adult central nervous system (CNS). We have examined the expression of LPA receptors 1-3 (LPA(1-3)) in intact mouse spinal cord and cortical tissues and following injury. In intact and injured tissues, LPA(1) was expressed by ependymal cells in the central canal of the spinal cord and was upregulated in reactive astrocytes following spinal cord injury. LPA(2) showed low expression in intact CNS tissue, on grey matter astrocytes in spinal cord and in ependymal cells lining the lateral ventricle. Following injury, its expression was up..View full abstract
Awarded by NHMRC
This work was supported by NHMRC Project Grants 454723 and 454384, an NHMRC-Senior Research Fellowship (A.M.T.) and a SpinalCure Australia Research Fellowship (Y.G.).