PEDF regulates osteoclasts via osteoprotegerin and RANKL
Toru Akiyama, Crispin R Dass, Yusuke Shinoda, Hirotaka Kawano, Sakae Tanaka, Peter FM Choong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010
Bone homeostasis is maintained through a balance between bone formation and resorption. Bone resorption is mainly carried out by a specific type of cell called the osteoclast (OCL). Previously, expression of pigment epithelium-derived factor (PEDF), the most potent endogenous inhibitor of angiogenesis, has been demonstrated in bone tissue and it known to induce differentiation in osteoblastic cells. Furthermore, therapeutic effects of PEDF on osteosarcoma, a prevalent primary bone tumor, with inhibition of bone destruction has been shown. Thus, PEDF is possibly involved in bone homeostasis as an inhibitor of bone resorption. To address this involvement, we studied the effect of PEDF on OCL f..View full abstract
This study was supported by funding from the Australian Orthopaedics Association, the Victorian Orthopaedics Research Trust, and St Vincent's Hospital Melbourne.