Journal article

The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia

Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J Rogerson, Steven R Meshnick

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | ELSEVIER SCIENCE INC | Published : 2010

Abstract

Plasmodium falciparum infection during pregnancy causes maternal anemia and low birth weight (LBW), but the effect of frequency and timing of infection on the severity of these adverse effects is unknown. We conducted a cohort study recruiting 2462 pregnant women in Malawi. Microscopy was used to diagnose malaria at enrollment, follow-up and delivery. Birth weight and maternal hemoglobin were measured at delivery. The association between timing and frequency of infection and LBW and maternal anemia was analyzed using a binomial regression model. Compared with uninfected women, (i) the risk of LBW increased with the number of malaria episodes [one episode: prevalence ratio (PR) 1.62 (95% CI 1..

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Funding Acknowledgements

This study was funded by CDC grant CDC/ASPH/ASTDR S1935-21/21. SJR was supported by a Wellcome Trust Senior Research Fellowship. LK was funded by a grant from the Fogarty International Center, 2D43TW006568. The CDC had no role in the design and conduct of the study, data collection, analysis and interpretation of the data, in the preparation, review, or approval of the manuscript.