Journal article

Peptide Nucleic Acid Films and Capsules: Assembly and Enzymatic Degradation

Alisa L Becker, Angus PR Johnston, Frank Caruso

MACROMOLECULAR BIOSCIENCE | WILEY-V C H VERLAG GMBH | Published : 2010

Abstract

Sequence-directed hybridization of nucleic acids provides a high level of control for the bottom-up assembly of nanostructured materials. Altering the DNA sequence affords control and versatility over the film structure, but is limited by the chemical and physical properties of DNA. Here, we use DNA analogues, peptide nucleic acids (PNAs), to introduce new properties to multilayered thin films and retain the advantages of sequence-directed assembly. Thin films, formed by the layer-by-layer (LbL) assembly of PNA strands, were assembled from short PNA sequences on planar and colloidal substrates. In the case of PNA-coated particles, hollow capsules were obtained following removal of the sacrif..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes. The Particulate Fluids Processing Centre (The University of Melbourne) is acknowledged for infrastructure support. The authors thank Lillian Lee and Francesca Cavalieri for helpful discussions.