Journal article

C-Reactive Protein and Age-Related Macular Degeneration and Cataract: The Singapore Malay Eye Study

Pui Yi Boey, Wan Ting Tay, Ecosse Lamoureux, E Shyong Tai, Paul Mitchell, Jie Jin Wang, Seang Mei Saw, Tien Yin Wong

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2010

Abstract

Purpose. To describe associations between C-reactive protein (CRP) and age-related macular degeneration (AMD) and cataract in an Asian population. Methods. A population-based, cross-sectional study of 3280 (78.7% response) Malay persons aged 40 to 80 years was conducted in Singapore. Wisconsin grading protocols were used to grade retinal photographs for signs of early and late AMD, and lens photographs were assessed for nuclear, cortical, and posterior subcapsular (PSC) cataract. Venous blood samples were assessed for serum CRP. Results. Of 3100 (94.5%) subjects with gradable fundus photographs, 177 (5.7%) had any AMD, 155 (5.0%) early AMD, and 22 (0.7%) late AMD. No association was found be..

View full abstract

Grants

Awarded by National Medical Research Council


Awarded by Biomedical Research Council


Funding Acknowledgements

Supported by National Medical Research Council Grants 0796/2003, 0863/2004, and CSI/0002/2005 and Biomedical Research Council Grant 501/1/25-5. The sponsors had no role in the study design, acquisition of data, statistical analysis, and interpretation, and the final presentation and publication of the study.