C-reactive protein and age-related macular degeneration and cataract: The Singapore Malay eye study

PY Boey; WT Tay; E Lamoureux; E Shyong Tai; P Mitchell; JJ Wang; SM Saw; TY Wong

Journal article

C-reactive protein and age-related macular degeneration and cataract: The Singapore Malay eye study

PY Boey, WT Tay, E Lamoureux, E Shyong Tai, P Mitchell, JJ Wang, SM Saw, TY Wong

Investigative Ophthalmology and Visual Science | Published : 2010

DOI: 10.1167/iovs.09-4063

Abstract

PURPOSE. To describe associations between C-reactive protein (CRP) and age-related macular degeneration (AMD) and cataract in an Asian population. METHODS. A population-based, cross-sectional study of 3280 (78.7% response) Malay persons aged 40 to 80 years was conducted in Singapore. Wisconsin grading protocols were used to grade retinal photographs for signs of early and late AMD, and lens photographs were assessed for nuclear, cortical, and posterior subcapsular (PSC) cataract. Venous blood samples were assessed for serum CRP. RESULTS. Of 3100 (94.5%) subjects with gradable fundus photographs, 177 (5.7%) had any AMD, 155 (5.0%) early AMD, and 22 (0.7%) late AMD. No association was found be..

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University of Melbourne Researchers

Ecosse Lamoureux Author

Grants

Awarded by National Medical Research Council

Awarded by Biomedical Research Council

Funding Acknowledgements

Supported by National Medical Research Council Grants 0796/2003, 0863/2004, and CSI/0002/2005 and Biomedical Research Council Grant 501/1/25-5. The sponsors had no role in the study design, acquisition of data, statistical analysis, and interpretation, and the final presentation and publication of the study.