Journal article

Motor Unit Recruitment in Human Genioglossus Muscle in Response to Hypercapnia

Christian L Nicholas, Bei Bei, Christopher Worsnop, Atul Malhotra, Amy S Jordan, Julian P Saboisky, Julia KM Chan, Ella Duckworth, David P White, John Trinder

SLEEP | OXFORD UNIV PRESS INC | Published : 2010

Abstract

STUDY OBJECTIVES: single motor unit recordings of the genioglossus (GG) muscle indicate that GG motor units have a variety of discharge patterns, including units that have higher discharge rates during inspiration (inspiratory phasic and inspiratory tonic), or expiration (expiratory phasic and expiratory tonic), or do not modify their rate with respiration (tonic). Previous studies have shown that an increase in GG muscle activity is a consequence of increased activity in inspiratory units. However, there are differences between studies as to whether this increase is primarily due to recruitment of new motor units (motor unit recruitment) or to increased discharge rate of already active unit..

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Grants


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

The project was supported by grants NHMRC-454458 and NIH-1R01HL085188-01A2This was not an industry supported study. Dr. Nicholas has received research support from Ventus Medical. Dr. Worsnop has participated in speaking engagements for GlaxoSmithKline, AstraZeneca, Pfizer, Boehringer Ingelheim, Schering Plough, Elsevier, and Nycomed. Dr. Malhotra has received research support and/or consulted for Philips, Pfizer, Cephalon, Sepracor, Itamar, NMT, SGS, Apnex, Novartis, Ethicon, and Medtronic. Dr. White is Chief Medical Officer for Philips Respironics and consults for Itamar Medical. The other authors have indicated no financial conflicts of interest.