Journal article
Plasminogen activator inhibitor-1 (PAI-1) activity and retinal vascular calibre in type 2 diabetes
L Brazionis, J Yau, K Rowley, C Itsiopoulos, K O'Dea, TY Wong, A Jenkins
Diabetes Research and Clinical Practice | ELSEVIER IRELAND LTD | Published : 2010
Abstract
Objective: To describe relationships of retinal vascular calibre with plasminogen activator inhibitor-1 (PAI-1) and other cardiovascular risk factors in people with type 2 diabetes. Methods: We recruited 112 community-based persons aged 44-83 years with type 2 diabetes, photo-documented retinal status using a digital fundus camera, and measured traditional and novel vascular risk factors. Retinal arteriolar and venular calibre and the arterio-venous ratio (AVR) were determined from fundus photographs using a validated computer-assisted method. Results: In adjusted linear regression models, PAI-1 activity was strongly associated with all measures of retinal vascular calibre: positively with a..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work would not have been possible without the Melbourne Collaborative Cohort Study and the infrastructure support provided by the Cancer Council Victoria. Additional funding was provided by the National Health and Medical Research Council (#124317), the National Heart Foundation and the Centre for Clinical Research Excellence in Clinical Science in Diabetes.