Role of the Hepatocyte Growth Factor Gene in Refractive Error

S Veerappan; KK Pertile; AFM Islam; M Schäche; CY Chen; P Mitchell; M Dirani; PN Baird

Journal article

Role of the Hepatocyte Growth Factor Gene in Refractive Error

S Veerappan, KK Pertile, AFM Islam, M Schäche, CY Chen, P Mitchell, M Dirani, PN Baird

Ophthalmology | Published : 2010

DOI: 10.1016/j.ophtha.2009.07.002

Abstract

Objective: Refractive errors such as myopia and hypermetropia are among the leading causes of visual impairment worldwide. Several genetic loci have been associated with myopia but none to date have been reported for hypermetropia. We investigated the hepatocyte growth factor (HGF) as a candidate gene influencing these 2 refractive error states. Design: Case-control study. Participants: A total of 551 individuals (193 males, 358 females; mean age, 55.41±12.65 years) including 117 individuals with high myopia ≤ -6.00 diopters (D), 140 individuals with low/moderate myopia (-2.00 to -5.99 D), 148 emmetropic individuals (-0.50 to +0.75 D) and 146 hyperopic individuals (>+2.00 D) were included in..

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University of Melbourne Researchers

Paul Baird Author

Grants

Funding Acknowledgements

Supported by the Australian Federal Government through the Cooperative Research Centres Program, the National Health and Medical Research Council of Australia, Joan and Peter Clemenger Trust, Helen Macpherson Smith Trust, L. E. W Carty Trust, Angior Family Foundation, the Myra Stoicesco Charitable Trust as administered by Equity Trustees Ltd and the Sunshine Foundation.