Redundancy in the immune system restricts the spread of HSV-1 in the central nervous system (CNS) of C57BL/6 mice
Lorne F Kastrukoff, Allen S Lau, Fumio Takei, Mark J Smyth, Claerwen M Jones, Sally RM Clarke, Francis R Carbone
VIROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010
Resistance to lethal encephalitis in mice infected with HSV-1 via the oral mucosa is mouse strain dependent. In susceptible BALB/c, HSV-1 spreads throughout the CNS but in resistant BL/6 mice, virus is restricted to the brainstem. To examine the contribution of cellular immunity in restricting viral spread, we used a combination of antibody depleted and KO mice. Individually, NK/NKT, iNKT, CD4(+), CD8(+), and gammadelta T-cells do not restrict HSV-1 spread. In contrast, virus spreads throughout the CNS of BL/6 CL I KO mice and BL/6 mice treated with either anti-asialoGM1 Ab or both anti-CD8 and anti-NK1.1 mAbs. The results highlight the importance of redundancy in the immune system in restri..View full abstract
This work was supported by the Canadian Institutes of Health Research (grant to LF Kastrukoff). Funding to MJ Smyth is from The National Health and Medical Research Council of Australia Program Grant. The authors have no conflicting financial interests.