Antigen recognition by CD1d-restricted NKT T cell receptors
Dale I Godfrey, Daniel G Pellicci, Onisha Patel, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn
SEMINARS IN IMMUNOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2010
alphabeta T cell receptors (TCRs) have traditionally been viewed as receptors for peptide antigens presented by either Major Histocompatibility Complex (MHC) class I (for CD8 T cells) or MHC class II (for CD4 T cells) antigen-presenting molecules. However, it is now clear that some T cell lineages express TCRs that are specialized for recognition of lipid-based antigens presented by the MHC class I-like CD1 family. Recently, the molecular basis for the TCR recognition of glycolipid antigens presented by CD1d has revealed an evolutionarily conserved-docking mode that is distinct from that of peptide-based recognition. T cells carrying these receptors follow a unique developmental pathway that..View full abstract
DIG is supported by a National Health and Medical Research Council of Australia (NHMRC) Research Fellowship, JR is supported by an Australian Research Council Federation Fellowship and our research is supported by NHMRC, ARC and the Cancer Council of Victoria.