Journal article

Chemical Cross-Linking Gelatin with Natural Phenolic Compounds as Studied by High-Resolution NMR Spectroscopy

Xiaoqing Zhang, My Dieu Do, Philip Casey, Adrian Sulistio, Greg G Qiao, Leif Lundin, Peter Lillford, Shansha Kosaraju

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2010

Abstract

Cross-linking gelatin with natural phenolic compound caffeic acid (CA) or tannic acid (TA) above pH 9 resulted in formation of insoluble hydrogels. The cross-linking reactivity was controlled by variation of pH, the concentration of the gelatin solution, or the amount of CA or TA used in the reaction. The cross-linking chemistry was studied by high-resolution NMR technique in both solution and solid state via investigation on small molecular model systems or using (13)C enriched caffeic acid (LCA) in the reaction with gelatin. Direct evidence was obtained to confirm the chemical reactions occurring between the phenolic reactive sites of the phenolic compounds and the amino groups in gelatin ..

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University of Melbourne Researchers