Journal article

A minimum of two distinct heritable factors are required to explain correlation structures in proliferating lymphocytes

John F Markham, Cameron J Wellard, Edwin D Hawkins, Ken R Duffy, Philip D Hodgkin



During the adaptive immune response, lymphocyte populations undergo a characteristic three-phase process: expansion through a series of cell divisions; cessation of expansion; and, finally, most of the accumulated lymphocytes die by apoptosis. The data used, thus far, to inform understanding of these processes, both in vitro and in vivo, are taken from flow cytometry experiments. One significant drawback of flow cytometry is that individual cells cannot be tracked, so that it is not possible to investigate interdependencies in the fate of cells within a family tree. This deficit in experimental information has recently been overcome by Hawkins et al. (Hawkins et al. 2009 Proc. Natl Acad. Sci..

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Awarded by Science Foundation Ireland

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

J.F.M. was supported by National ICT Australia (NICTA), which is funded by the Australian Government's Backing Australia's Ability initiative, in part through the Australian Research Council. The work by K.R.D. was supported by the Science Foundation Ireland grant SFI/07/ENEF530-STTF-08. P. D. H. and E. D. H. each are supported by Australian National Health and Medical Research Council (NHMRC) Fellowships. The work by C.J.W. was supported by NHMRC grant 461240. Finally, we thank W. H. Robinson for inspiration and helpful input to this manuscript. The data used in this study are available from the Hodgkin Laboratory's website (