Journal article
Multilayer buildup and biofouling characteristics of PSS-b-PEG containing films
C Cortez, JF Quinn, X Hao, CS Gudipati, MH Stenzel, TP Davis, F Caruso
Langmuir | AMER CHEMICAL SOC | Published : 2010
DOI: 10.1021/la100430g
Abstract
Thin films exhibiting protein resistance are of interest in diverse areas, ranging from low fouling surfaces in biomedicine to marine applications. Herein, we report the preparation of low protein and cell binding multilayer thin films, formed by the alternate deposition of a block copolymer comprising polystyrene sulfonate and poly(poly(ethylene glycol) methyl ether acrylate) (PSS-b-PEG), and polyallylamine hydrochloride (PAH). Film buildup was followed by quartz crystal microgravimetry (QCM), which showed linear growth and a high degree of hydration of the PSS-b-PEG/PAH films. Protein adsorption studies with bovine serum albumin using QCM demonstrated that multilayer films of PSS/PAH with ..
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Funding Acknowledgements
This work was supported by the Australian Research Council under the Discovery Project and Federation Fellowship schemes. The authors wish to acknowledge J. K. Heath at the Ludwig Institute for Cancer Research, Melbourne for the LIM1215 cells and the use of the cell culture facility.