Journal article
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
H Quach, D Ritchie, AK Stewart, P Neeson, S Harrison, MJ Smyth, HM Prince
Leukemia | Published : 2010
DOI: 10.1038/leu.2009.236
Abstract
Immunomodulatory drugs (IMiDs) are thalidomide analogues, which possess pleiotropic anti-myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and anti-proliferative effects. Their development was facilitated by an improved understanding in myeloma (MM) biology and initiated a profound shift in the therapeutic approach towards MM. Despite the diverse effects of IMiDs in vitro, the relative contribution of each effect towards their ultimate anti-MM activity is still unclear. Based on in vitro data, it appears that anti-proliferative effects and downregulation of crucial cytokines are their most important anti-MM attributes. Although the co-stimulatory effects on T..
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Awarded by National Cancer Institute
Funding Acknowledgements
We acknowledge the insightful comments and critical review of the article by A/Prof S Opat, P Schafer, and Dr H Tran. Dr Hang Quach received funding support from the Vincent Fairfax Scholarship (Royal Australasian College of Physicians), and the Peter MacCallum Foundation (Morris Family Grant).