Journal article

The frequency, manifestations, and duration of prolonged cytopenias after first-line fludarabine combination chemotherapy

S Gill, D Carney, D Ritchie, M Wolf, D Westerman, HM Prince, H Januszewicz, JF Seymour

ANNALS OF ONCOLOGY | OXFORD UNIV PRESS | Published : 2010

Abstract

BACKGROUND: Fludarabine-based chemoimmunotherapy has well-recognised efficacy and short-term toxicity in the treatment of lymphoid malignancies. However, the presence and significance of prolonged cytopenias after completion of treatment have not been thoroughly quantified. METHODS: Sixty-one patients receiving initial therapy with fludarabine-based regimens were categorised according to the presence of post-treatment cytopenias (haemoglobin <110-130 g/l depending on sex and age, neutrophils <2.0 x 10(9)/l, or platelets 3 months. RESULTS: Persistent cytopenias unrelated to persistent disease were found in 43% of patients. Cytopenias were associated with clinically important rates of infectio..

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