Journal article

Elucidating the transcriptome of Fasciola hepatica - A key to fundamental and biotechnological discoveries for a neglected parasite

Neil D Young, Ross S Hall, Aaron R Jex, Cinzia Cantacessi, Robin B Gasser



Liver flukes of animals are parasitic flatworms (Platyhelminthes: Digenea) of major socioeconomic importance in many countries. Key representatives, such as Fasciola hepatica and F. gigantica, cause "liver fluke disease" (= fascioliasis), which is of major animal health significance worldwide. In particular, F. hepatica is a leading cause of production losses to the livestock (mainly sheep and cattle) and meat industries due to clinical disease, reduced weight gain and milk production, and deaths. This parasite is also a major food-borne pathogen of humans throughout parts of the Middle East, Asia and South America. Currently, there is a significant focus on the development of new approaches..

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Funding Acknowledgements

We thank members of the Victorian Life Sciences Initiative (VLSI) and the Victorian Partnership for Advanced Computing (VPAC). Current research in the Gasser Laboratory is supported by the Australian Research Council (ARC), Melbourne Water Corporation, Meat and Livestock Australia Limited (MLA) and the National Health and Medical Research Council (NHMRC).