Functional role of alpha(2)-adrenoceptor subtypes in the cooling-enhanced vasoconstriction of isolated cutaneous digital veins of the horse
Hector Zerpa, Yoel Berhane, Jonathan Elliott, Simon R Bailey
European Journal of Pharmacology | ELSEVIER | Published : 2010
Cooling-enhanced contractile responses in cutaneous arteries have been reported to involve the activation of alpha(2C)-adrenoceptors, but their role in cutaneous veins is not clearly understood. The aim was to pharmacologically characterize the subtype of postsynaptic alpha(2)-adrenoceptors in the equine digital vein mediating contraction at two temperatures. The increase in isometric tension of endothelium-denuded equine digital vein in response to UK-14304 was studied in the absence and presence of relatively selective alpha(2)-adrenoceptor antagonists at temperatures of either 30 degrees C (the peripheral digit temperature of horses maintained in a thermoneutral environment) or 22 degrees..View full abstract
Awarded by European Union Programme of Scholarships for Latin America
HZ was supported by CDCH-UCV and the Programme AlBan, the European Union Programme of Scholarships for Latin America, scholarship No. E05D054410VE. The authors are also grateful to Dr. Medardo Hernandez for a fruitful discussion of the manuscript and Helen Woodcock for her technical support.