Journal article

Increased tissue kallikrein levels in type 2 diabetes

DJ Campbell, A Kladis, Y Zhang, AJ Jenkins, DL Prior, M Yii, JF Kenny, MJ Black, DJ Kelly

DIABETOLOGIA | SPRINGER | Published : 2010

Abstract

AIMS/HYPOTHESIS: We measured components of the kallikrein- kinin system in human type 2 diabetes mellitus and the effects of statin therapy on the circulating kallikrein-kinin system. METHODS: Circulating levels of bradykinin and kallidin peptides, and high and low molecular weight kininogens, as well as plasma and tissue kallikrein, and kallistatin were measured in non-diabetic and diabetic patients before coronary artery bypass graft surgery. Tissue kallikrein levels in atrial tissue were examined by immunohistochemistry and atrial tissue kallikrein mRNA quantified. RESULTS: Plasma levels of tissue kallikrein were approximately 62% higher in diabetic than in non-diabetic patients (p=0.001)..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

Davis for assistance with measurement of carboxymethyl lysine and LMWF levels. This work was funded by grants from the National Health and Medical Research Council of Australia and from the National Heart Foundation of Australia. D. J. Campbell (Grant ID 395508) and D. J. Kelly (Grant ID 566867) are recipients of Senior Research Fellowships from the National Health and Medical Research Council of Australia.