Journal article

Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine

A Ferrand, S Lachal, G Bramante, S Kovac, A Shulkes, GS Baldwin

American Journal of Physiology - Gastrointestinal and Liver Physiology | Published : 2010


Precursors of the peptide hormone gastrin stimulate proliferation in the colorectal mucosa and promote the development of colorectal carcinoma. Gastrins bind two ferric ions selectively and with high affinity, and the biological activity of glycine-extended gastrin (Ggly) in vitro is dependent on the presence of ferric ions. The aim of the present study was to determine whether or not iron is required for biological activity of progastrin and Ggly in vivo. Rats that had undergone a colostomy were infused with Ggly, and proliferation was measured in the defunctioned rectal mucosa. Proliferation was also measured in the colonic mucosa of hGAS and MTI-Ggly mice, which, by definition, overexpres..

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