Journal article
Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation
K Butcher, S Christensen, M Parsons, DA De Silva, M Ebinger, C Levi, T Jeerakathil, BCV Campbell, PA Barber, C Bladin, J Fink, B Tress, GA Donnan, SM Davis
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
Abstract
BACKGROUND AND PURPOSE-: Reliable predictors of hemorrhagic transformation (HT) after stroke thrombolysis have not been identified. We analyzed hemorrhage in a randomized trial of tissue plasminogen activator (t-PA) vs placebo in ischemic stroke patients. We hypothesized that acute diffusion-weighted imaging (DWI) lesion volumes would be larger and blood pressures would be higher in patients with HT. METHODS-: HT was assessed 2 to 5 days after treatment in 97 patients. Hemorrhage was assessed by using susceptibility-weighted imaging sequences and was classified as petechial hemorrhagic infarction (HI) or parenchymal hematoma (PH). RESULTS-: PH was more frequent in t-PA-(11/49) than in placeb..
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Funding Acknowledgements
The investigator-led EPITHET was supported by the National Health and Medical Research Council of Australia.