Journal article
The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the echoplanar imaging thrombolytic evaluation trial (EPITHET)
DA De Silva, C Brekenfeld, M Ebinger, S Christensen, PA Barber, KS Butcher, CR Levi, MW Parsons, CF Bladin, GA Donnan, SM Davis
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
Abstract
Background and Purpose-In ischemic stroke, the site of arterial obstruction has been shown to influence recanalization and clinical outcomes. However, this has not been studied in randomized controlled trials, nor has the impact of arterial obstruction site on reperfusion and infarct growth been assessed. We studied the influence of site and degree of arterial obstruction patients enrolled in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET). Methods-EPITHET was a prospective, randomized, placebo-controlled trial of intravenous tissue plasminogen activator (tPA) in the 3-to 6-hour time window. Arterial obstruction site and degree were rated on magnetic resonance angiography blin..
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Funding Acknowledgements
[ "Royal Melbourne Hospital Neurosciences Foundation.", "D. A. D. S. has accepted honoraria or consultancy and travel grants from Pfizer. K. S. B. has accepted honoraria or consultancy and travel grants from Boehinger-Ingelheim, Sanofi-Aventis, and Roche. C. R. L., M. W. P., and C. F. B. have accepted honoraria or consultancy and travel grants from Boehinger-Ingelheim and Sanofi-Aventis. G. A. D. is a member of Boehinger-Ingelheim, PAION, Servier, and Sanofi- Aventis advisory boards. S. M. D. is a member of Servier, Novo Nordisk, and Sanofi-Aventis advisory boards." ]