Journal article

The Role of Epigenetics in the Acquisition and Maintenance of Effector Function in Virus-Specific CD8 T Cells

Matthew R Olson, Brendan E Russ, Peter C Doherty, Stephen J Turner

IUBMB LIFE | WILEY | Published : 2010

Abstract

CD8(+) T cells are critical for protecting the body from infectious disease. To achieve this protection, CD8(+) T cells must undergo a highly involved process of differentiation that involves the activation of naïve/quiescent cells followed by robust rounds of cell division and the acquisition of effector functions that mediate viral clearance. After the pathogen is eliminated, a small number of these cells survive into long-lived memory and maintain the capacity to respond rapidly and reacquire effector function after secondary exposure to their cognate antigen. This review focuses on how CD8(+) T cells acquire and regulate effector functions and how the capacity to produce effector molecul..

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