The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI

Abstract

Background and Purpose: Many perfusion-related MRI parameters are used to investigate the penumbra in stroke. Although time-to-maximum (Tmax) of the residue function has been suggested as a very promising parameter, its physiological meaning and sensitivity to experimental conditions are not well-understood. Methods: We used simulations to further our understanding of the practical meaning of Tmax and to provide recommendations for its use in clinical investigations. We interpret in vivo examples guided by the simulation findings. RESULTS: Whereas Tmax has several attractive properties for clinical use, it is shown that its physiological interpretation is complex and affected by experimental..