The Shifting Trajectory of Growth in Femur Length During Gestation
Ashild Bjornerem, Synnove L Johnsen, Tuan V Nguyen, Torvid Kiserud, Ego Seeman
JOURNAL OF BONE AND MINERAL RESEARCH | JOHN WILEY & SONS INC | Published : 2010
Bone size is a determinant of bone strength and tracks in its percentile of origin during childhood and adolescence. We hypothesized that the ranking of an individual's femur length (FL) is established in early gestation and tracks thereafter. Fetal FL was measured serially using 2D ultrasound in 625 Norwegian fetuses. Tracking was assessed using Pearson correlation, a generalized estimating equation model, and by calculating the proportion of fetuses whose FL remained within the same quartile. Baseline FL Z-score (weeks 10 to 19) and later measurements correlated, but more weakly as gestation advanced: r = 0.59 (weeks 20 to 26); r = 0.45 (weeks 27 to 33); and r = 0.32 (weeks 34 to 39) (p < ..View full abstract
This work was funded by the Research Council of Norway and the Haukeland University Hospital.