AMPK-mediated regulation of transcription in skeletal muscle
Sean L McGee, Mark Hargreaves
CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2010
Skeletal muscle phenotype plays a critical role in human performance and health, and skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently, defective muscle oxidative metabolism has been implicated in a number of conditions associated with the metabolic syndrome, cardiovascular disease and muscle-wasting disorders. AMPK (AMP-activated protein kinase) is a critical regulator of cellular and organismal energy balance. AMPK has also emerged as a key regulator of skeletal muscle oxidative function, including metabolic enzyme expression, mitochondrial biogenesis and angiogenesis. AMPK mediates these processes primarily through alterations in gene expression...View full abstract
S.L.M. is supported by the Diabetes Research Trust Viertel Award.