Journal article

Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen

Wee Kian Yeo, Sean L McGee, Andrew L Carey, Carl D Paton, Andrew P Garnham, Mark Hargreaves, John A Hawley



We have previously demonstrated that well-trained subjects who completed a 3 week training programme in which selected high-intensity interval training (HIT) sessions were commenced with low muscle glycogen content increased the maximal activities of several oxidative enzymes that promote endurance adaptations to a greater extent than subjects who began all training sessions with normal glycogen levels. The aim of the present study was to investigate acute skeletal muscle signalling responses to a single bout of HIT commenced with low or normal muscle glycogen stores in an attempt to elucidate potential mechanism(s) that might underlie our previous observations. Six endurance-trained cyclist..

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University of Melbourne Researchers


Funding Acknowledgements

This study was supported by a research grant from Glaxo SmithKline (UK) to J.A.H., the Australian Sports Commission (J.A.H.) and the National Sports Council of Malaysia (W.K.Y.). A.L.C. and S.L.M. are supported by Peter Doherty post doctoral fellowships from the National Health and Medical Research Council. The authors would like to thank Professor Bruce Kemp for his kind gift of the AMPK antibodies and Professor Louise Burke for help with nutritional interventions.