DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females
Helen E MacLean, Alison J Moore, Stephen A Sastra, Howard A Morris, Ali Ghasem-Zadeh, Kesha Rana, Anna-Maree Axell, Amanda J Notini, David J Handelsman, Ego Seeman, Jeffrey D Zajac, Rachel A Davey
JOURNAL OF ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2010
We used our genomic androgen receptor (AR) knockout (ARKO) mouse model, in which the AR is unable to bind DNA to: 1) document gender differences between males and females; 2) identify the genomic (DNA-binding-dependent) AR-mediated actions in males; 3) determine the contribution of genomic AR-mediated actions to these gender differences; and 4) identify physiological genomic AR-mediated actions in females. At 9 weeks of age, control males had higher body, heart and kidney mass, lower spleen mass, and longer and larger bones compared to control females. Compared to control males, ARKO males had lower body and kidney mass, higher splenic mass, and reductions in cortical and trabecular bone. De..View full abstract
Awarded by NHMRC
Awarded by NHMRC Career Development
This research was supported by NHMRC Project Grants #350334 and #350346 and an Eva and Les Erdi Research Grant; HEM was supported by NHMRC Career Development Award #359226.