Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin
Fiona Newall, Vera Ignjatovic, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick, Paul Monagle
THROMBOSIS AND HAEMOSTASIS | SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN | Published : 2010
Previous studies investigating continuous unfractionated heparin (UFH) therapy report age-related differences in UFH response in children, as measured by APTT and anti-Xa assay. This study determined the age-related response following administration of a single UFH bolus of 75-100 IU/kg in children. Venous blood samples were collected from children (n=56) at 15, 30, 45 and 120 minutes post-UFH. Anti-Xa, anti-IIa, APTT, TCT and protamine titration were performed on all samples. Age-dependent differences in the effect and concentration of UFH were identified for the anti-Xa, anti-IIa and protamine titration assays, respectively. In addition, a trend suggesting a proportional increase in anti-X..View full abstract
Awarded by NHMRC
This project was supported by an NHMRC Research Grant #454385. Dr Ignjatovic is supported by the Sanofi-Aventis Clinical Research Fellowship. Fiona Newall held an Australian Postgraduate Award.