Journal article

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

Freya JI Fowkes, Jack S Richards, Julie A Simpson, James G Beeson



BACKGROUND: One of the criteria to objectively prioritize merozoite antigens for malaria vaccine development is the demonstration that naturally acquired antibodies are associated with protection from malaria. However, published evidence of the protective effect of these antibodies is conflicting. METHODS AND FINDINGS: We performed a systematic review with meta-analysis of prospective cohort studies examining the association between anti-merozoite immunoglobin (Ig) G responses and incidence of Plasmodium falciparum malaria. Two independent researchers searched six databases and identified 33 studies that met predefined inclusion and quality criteria, including a rigorous definition of sympto..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia (NHMRC, project grant #516756, NHMRC IRIISS grant #361646 and the Victorian State Government Operational Infrastructure Support grant. JGB is supported by a Clinical Career Development Award, and JSR by a Medical Postgraduate Research Scholarship from the NHMRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.