Elucidating ANTS in worms using genomic and bioinformatic tools - Biotechnological prospects?
Min Hu, Weiwei Zhong, Bronwyn E Campbell, Paul W Sternberg, Mark W Pellegrino, Robin B Gasser
BIOTECHNOLOGY ADVANCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2010
Adenine nucleotide translocators (ANTs) belong to the mitochondrial carrier family (MCF) of proteins. ATP production and consumption are tightly linked to ANTs, the kinetics of which have been proposed to play a key regulatory role in mitochondrial oxidative phosphorylation. ANTs are also recognized as a central component of the mitochondrial permeability transition pore associated with apoptosis. Although ANTs have been investigated in a range of vertebrates, including human, mouse and cattle, and invertebrates, such as Drosophila melanogaster (vinegar fly), Saccharomyces cerevisiae (yeast) and Caenorhabditis elegans (free-living nematode), there has been a void of information on these mole..View full abstract
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Awarded by Australian Research Council
Funding support to RBG from the Australian Research Council (LX0882231 and LX0989150), Genetic Technologies Limited and Meat and Livestock Australia are gratefully acknowledged. The authors thank Drs Warwick Grant, Kirsten Grant and Jagan Srinivasan for discussions and support as well as Alon Zaslaver for technical assistance.