A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease

Abstract

The primary constituent of the amyloid plaque, β-amyloid (Aβ), is thought to be the causal "toxic moiety" of Alzheimer's disease. However, despite much work focused on both Aβ and its parent protein, amyloid precursor protein (APP), the functional roles of APP and its cleavage products remain to be fully elucidated. Protein-protein interaction networks can provide insight into protein function, however, high-throughput data often report false positives and are in frequent disagreement with low-throughput experiments. Moreover, the complexity of the CNS is likely to be under represented in such databases. Therefore, we curated the published work characterizing both APP and Aβ to create a prot..