ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity
Michelle J Porritt, Michelle Chen, Sarah SJ Rewell, Rachael G Dean, Louise M Burrell, David W Howells
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | SAGE PUBLICATIONS INC | Published : 2010
Angiotensin-converting enzyme (ACE) inhibition can reduce stroke risk by up to 43% in humans and reduce the associated disability, and hence understanding the mechanism of improvement is important. In animals and humans, these effects may be independent of the blood pressure-lowering effects of ACE inhibition. Normotensive (Wistar-Kyoto (WKY)) and hypertensive (spontaneously hypertensive rat (SHR)) animals were treated with the ACE inhibitors ramipril or lisinopril for 7 or 42 days before 2 hours of transient middle cerebral artery occlusion (MCAo). Blood pressure, serum ACE, and blood glucose levels were measured and stroke infarct volume was recorded 24 hours after stroke. Despite greater ..View full abstract
DWH and LMB received research funding from the National Health and Medical Research Council of Australia.