Cross- reactive CD8( ) T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses
Stephanie Gras, Lukasz Kedzierski, Sophie A Valkenburg, Karen Laurie, Yu Chih Liu, Justin T Denholm, Michael J Richards, Guus F Rimmelzwaan, Anne Kelso, Peter C Doherty, Stephen J Turner, Jamie Rossjohn, Katherine Kedzierska
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2010
Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery from influenza virus infections, with there being some evidence of cross-protection directed at variable peptides. Strikingly, many of the immunogenic peptides derived from the current pandemic A(H1N1)-2009 influenza virus are representative of the catastrophic 1918 "Spanish flu" rather than more recent "seasonal" strains. We present immunological and structural analyses of cross-reactive CD8(+) T-cell-mediated immunity directed at a variable (although highly cross-reactive) immunodominant NP(418-426) peptide that binds to a large B7 family (HLA-B*3501/03/0702) found throughout human populations. Memor..View full abstract
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Awarded by Australian National Health and Medical Research Council
We thank Dr. Mandvi Bharadwaj and Ms. Amabel Tan for valuable discussions. This work was funded by Grant 628965 from the Australian National Health and Medical Research Council Urgent Call for Research on H1N1 Influenza 09 (to K.K., S.J.T., A.K., and J.R.) and the Australian National Health and Medical Research Council program (to P.C.D., A.K., and S.J.T.) (AI567122). K.K. is an Australian National Health and Medical Research Council R. D. Wright Fellow, S.J.T. is a Pfizer Senior Research Fellow, and J.R. is an Australian Research Council Federation Fellow. S.A.V. is a recipient of the Australian Postgraduate Award. The Melbourne World Health Organization Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.