Stability of intravenous flucloxacillin solutions used for hospital-in-the-home

Abstract

Background: Despite the uncertainty regarding flucloxacillin's stability, flucloxacillin solutions are routinely used as 24-hour ambulatory infusions for hospital-in-the-home patients. Aim: To determine the stability of flucloxacillin solutions in a simulated hospital-in-the-home environment and to assess whether flucloxacillin loss can be minimised via pH control. Method: Samples of flucloxacillin 5% and 12% solutions were prepared with either sodium chloride 0.9% or water for injection and with or without 5 mL phosphate buffer (0.384 M; pH 7). Flucloxacillin 5% solutions were tested in elastomeric infusion devices and the 12% solutions in polyvinyl chloride bags. All of the solutions were ..