Journal article
Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009
NV Thanh, TQ Toan, AF Cowman, GJ Casey, BQ Phuc, NT Tien, NM Hung, BA Biggs
Malaria Journal | BMC | Published : 2010
Abstract
Background. Artemisinin derivatives have been used for malaria treatment in Vietnam since 1989. Reported malaria cases have decreased from 1,672,000 with 4,650 deaths in 1991, to 91,635 with 43 deaths in 2006. Current national guidelines recommend artemisinin-based combination therapy (ACT), although artesunate is still available as monotherapy through the private sector. Recent reports suggest that effectiveness of ACT and artesunate monotherapy has declined in western Cambodia. This study examined Plasmodium falciparum resistance patterns over 10 years in southwest Vietnam in infected patients treated with artemisinin compounds. Methods. The study was conducted in two communes in Phuoc Lon..
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Funding Acknowledgements
The authors acknowledge NIMPE and Binh Phuoc provincial and commune staff for assistance in conducting the surveys and assays. We thank the patients for taking part in the research. We are grateful to Dr. Pascal Ringwald for technical advice and reviewing the manuscript, and Pham Thi Xuyen, Marian Cravino, Beth Hilton-Thorp and Christalla Hajisava for administrative assisstance. Atlantic Philanthropy Incorporated kindly funded the project.