High throughput static and dynamic small animal imaging using clinical PET/CT: potential preclinical applications
Nicolas Aide, Cedric Desmonts, Jean-Mathieu Beauregard, Thomas Beyer, Kathryn Kinross, Peter Roselt, Oliver Neels, Denis Agostini, Stephane Bardet, Gerard Bouvard, Rodney J Hicks
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | SPRINGER | Published : 2010
PURPOSE: The objective of the study was to evaluate state-of-the-art clinical PET/CT technology in performing static and dynamic imaging of several mice simultaneously. METHODS: A mouse-sized phantom was imaged mimicking simultaneous imaging of three mice with computation of recovery coefficients (RCs) and spillover ratios (SORs). Fifteen mice harbouring abdominal or subcutaneous tumours were imaged on clinical PET/CT with point spread function (PSF) reconstruction after injection of [18F]fluorodeoxyglucose or [18F]fluorothymidine. Three of these mice were imaged alone and simultaneously at radial positions -5, 0 and 5 cm. The remaining 12 tumour-bearing mice were imaged in groups of 3 to es..View full abstract
This work was supported by a grant from the French Ligue contre le cancer, comite du calvados and by a Fellowship from the Fondation de France.