Journal article

Clinical significance of the positive surgical margin based upon location, grade, and stage

Neil E Fleshner, Andrew Evans, Karen Chadwick, Nathan Lawrentschuk, Alexandre Zlotta

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | ELSEVIER SCIENCE INC | Published : 2010

Abstract

Prostate cancer remains a challenge due to its incidence and radical prostatectomy continues to be a major treatment option for men with potentially curable disease who have a life expectancy over a decade. This article will address the common problem of positive surgical margins and the impact of them on patient outcome. Through these we can examine relevant clinical trials that have attempted to address this issue and offer some guided to therapy among men with this clinical problem. Close margins are probably of no significance and will not be addressed. Our recommendations take into account the current level of medical evidence, and are balanced with anticipated adverse effects of treatm..

View full abstract