Journal article
High-contrast PET of melanoma using 18F-MEL050, a selective probe for melanin with predominantly renal clearance
D Denoyer, I Greguric, P Roselt, OC Neels, N Aide, SR Taylor, A Katsifis, DS Dorow, RJ Hicks
Journal of Nuclear Medicine | Published : 2010
Abstract
The aim of this study was to evaluate the novel probe 18F-6- fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18F-MEL050 was performed in murine models of melanoma. The specificity of 18F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. 18F-MEL050 PET results were compared with 18F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of 18F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, ..
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Funding Acknowledgements
We gratefully acknowledge Laura Kirby, Susan Jackson, Rachael Walker, Kerry Ardley, Jiang Donghai, and Jeannette Valentan for their technical assistance and the radiochemistry team from Cyclotek (Aust) Pty Ltd. For financial support, we thank the Cooperative Research Centre for Biomedical Imaging Development Ltd. (CRCBID), established and supported under the Australian Government's Cooperative Research Centres program, and the Fondation de France.