Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes
E Assana, CG Gauci, CT Kyngdon, AP Zoli, P Dorny, S Geerts, MW Lightowlers
Parasite Immunology | WILEY | Published : 2010
TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against challenge infection with the cestode parasite Taenia solium. Antibodies raised by the vaccine are capable of killing the parasite in an in vitro culture and it is believed that antibody and complement-mediated killing of invading parasites is the major protective immune mechanism induced by vaccination with TSOL18. Investigations were undertaken to characterize whether the principal antibody specificities raised by TSOL18 in pigs were against linear or conformational determinants. TSOL18 was expressed in two truncated forms representing either the amino terminal portio..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Wellcome Trust
Funding is acknowledged from National Health and Medical Research Council, grants 350279, 400109, 628320 and from that The Wellcome Trust, grant 075818.