Journal article

Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea

Hayden Eastwood, Andrew Chang, Gordana Kel, David Sly, Rachael Richardson, Stephen J O'Leary



Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode array insertion. In this experiment, a second turn cochleostomy and implantation was performed on guinea pigs, to examine protection in the basal turn without the confounding effect of local trauma, as well as to test the efficacy of hearing protection in the second cochlear turn. The implantation resulted in an increase in hearing thresholds across all frequencies examined (2-32 kH..

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Awarded by NIDCD

Funding Acknowledgements

The authors wish to acknowledge the generous assistance of the Rodney Williams and Garnett Passe Memorial Foundation and NHMRC project grant for funding this project, The Royal Victorian Eye and Ear Hospital for providing facilities, Maria Clarke and Prudence Nielsen for preparation of histological slides, Associate Professor John L. Slavin (MBBS, FRCPA) and the St. Vincent's Hospital Melbourne, Anatomical Pathology Department for reviewing the histology, Dr. James Fallon for providing the ABR analysis program (NIDCD Contract HHS-N-263-2007-00053-C; PI: R.K. Shepherd) and Helen Feng for manufacturing the electrode arrays.