Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes
Maria A Doyle, Robin B Gasser, Ben J Woodcroft, Ross S Hall, Stuart A Ralph
BMC GENOMICS | BMC | Published : 2010
BACKGROUND: New drug targets are urgently needed for parasites of socio-economic importance. Genes that are essential for parasite survival are highly desirable targets, but information on these genes is lacking, as gene knockouts or knockdowns are difficult to perform in many species of parasites. We examined the applicability of large-scale essentiality information from four model eukaryotes, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus and Saccharomyces cerevisiae, to discover essential genes in each of their genomes. Parasite genes that lack orthologues in their host are desirable as selective targets, so we also examined prediction of essential genes within this subset...View full abstract
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Awarded by Australian Research Council (ARC)
The authors wish to thank the Wormbase, Flybase and MGI teams for assistance with data access. SAR is supported by a Future Fellowship (FT0990350) from the Australian Research Council (ARC). Financial support to the present study was provided by grants to RBG from the ARC.