Journal article
Pathophysiological determinants of worse stroke outcome in atrial fibrillation
HTH Tu, BCV Campbell, S Christensen, M Collins, DA De Silva, KS Butcher, MW Parsons, PM Desmond, PA Barber, CR Levi, CF Bladin, GA Donnan, SM Davis
Cerebrovascular Diseases | KARGER | Published : 2010
DOI: 10.1159/000316886
Abstract
Background: The reasons for worse outcome following ischemic stroke in patients with atrial fibrillation (AF) remain unclear. We aimed to elucidate the pathophysiological determinants of poorer stroke outcome in patients with AF using systematic MRI data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET). Methods: Comparisons of infarct size, hypoperfusion volume, infarct growth, arterial occlusion, recanalization, reperfusion, hemorrhagic transformation and stroke severity were made between patients with and without AF enrolled in the EPITHET study. Results: AF was present in 42 of 101 patients. At baseline, AF patients were older (79 vs. 73 years, p = 0.02), had more sever..
View full abstractGrants
Funding Acknowledgements
The EPITHET study was supported by the National Health and Medical Research Council of Australia, National Stroke Foundation and National Heart Foundation. This analysis was supported by the Royal Melbourne Hospital Neurosciences Foundation.