Journal article
Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy
SS O'Sullivan, A Djamshidian, Z Ahmed, AH Evans, AD Lawrence, JL Holton, T Revesz, AJ Lees
Movement Disorders | WILEY | Published : 2010
DOI: 10.1002/mds.22902
Abstract
There is growing awareness of impulsive-compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack patholo..
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Funding Acknowledgements
[ "This study was supported by the NIHR UCLH/UCL Comprehensive Biomedical Research Centre. SSOS, AJL, and JH are supported by the Reta Lila Weston Institute for Neurological Studies. JH, TR, and ZA are supported by the Sarah Matheson Trust for Multiple System Atrophy. JH and TR are supported by the Alzheimer's Research Trust, the Progressive Supranuclear Palsy (Europe) Association, and Brain Net Europe.", "Sean O'Sullivan: Has received honoraria from Britannia Pharmaceuticals. Employment: University College London. All other FD categories: None: Atbin Djamshidian: Employment: University College London. All other FD categories: None: Zeshan Ahmed: Employment: University College London. All other FD categories: None; Andrew Evans has served on advisory hoards and received honoraria from Boehringer Ingelheim, and Novartis. He has no other financial disclosures; Andrew Lawrence: Grants: UK Medical Research Council: UK Parkinson's Disease Society: Wales Institute of Cognitive Neuroscience. Employment: Cardiff University. All other categories: None: Janice Holton: Employment: University College London. All other FD categories: None; Minas Revesz: Employment: University College London. All other FD categories: None: Andrew Lees: advisory boards-Genus. Novartis. Teva, Medo, Boehringer Ingleheim, GSK, Ipsen, Lundbeck. Grants: PSP association, Reta Lila Weston Trust. All other categories: None." ]