Journal article

5-HT1A, SST1, and SST2 receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum

Jaime Pei Pei Foong, Laura J Parry, Rachel M Gwynne, Joel C Bornstein

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2010

Abstract

Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are the only submucosal neurons to receive inhibitory inputs and exhibit both noradrenergic and nonadrenergic inhibitory synaptic potentials (IPSPs). The former are mediated by alpha(2)-adrenoceptors, but the receptors mediating the latter have not been identified. We used standard intracellular recording, RT-PCR, and confocal microscopy to test whether 5-HT(1A), SST(1), and/or SST(2) receptors mediate nonadrenergic IPSPs in VIP submucosal neurons in guinea pig ileum in vitro. The specific 5-HT(1A) receptor antagonist WAY 100135 (1 microM) reduced the amplitude of IPSPs..

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Grants

Awarded by National Health and Medical Research Council Australia (NHMRC)


Funding Acknowledgements

The study was supported by a grant from the National Health and Medical Research Council Australia (NHMRC Grant No. 40053) and an Australian Postgraduate Award (J.P.P. Foong).