Sex-related physiology of the preimplantation embryo
David K Gardner, Mark G Larman, George A Thouas
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2010
Male and female preimplantation mammalian embryos differ not only in their chromosomal complement, but in their proteome and subsequent metabolome. This phenomenon is due to a finite period during preimplantation development when both X chromosomes are active, between embryonic genome activation and X chromosome inactivation, around the blastocyst stage. Consequently, prior to implantation male and female embryos exhibit differences in their cellular phenotype. Manifestations of such differences include altered total activity of specific X-linked enzymes and the metabolic pathways they regulate. Subsequently, one would expect to be able to determine differences in the rate of consumption and..View full abstract
The authors acknowledge support from The University of Melbourne and Vitrolife AB (Sweden) during the course of this work.