Journal article

Sex-related physiology of the preimplantation embryo

David K Gardner, Mark G Larman, George A Thouas

MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2010

Abstract

Male and female preimplantation mammalian embryos differ not only in their chromosomal complement, but in their proteome and subsequent metabolome. This phenomenon is due to a finite period during preimplantation development when both X chromosomes are active, between embryonic genome activation and X chromosome inactivation, around the blastocyst stage. Consequently, prior to implantation male and female embryos exhibit differences in their cellular phenotype. Manifestations of such differences include altered total activity of specific X-linked enzymes and the metabolic pathways they regulate. Subsequently, one would expect to be able to determine differences in the rate of consumption and..

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University of Melbourne Researchers