Journal article

A numerical model of neonatal pulmonary atresia with intact ventricular septum and RV-dependent coronary flow

JP Mynard, MR Davidson, DJ Penny, JJ Smolich

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING | WILEY-BLACKWELL | Published : 2010

Abstract

We developed a numerical model of the neonatal arterial and coronary circulations in the context of pulmonary atresia with intact ventricular septum (PAIVS). PAIVS is a congenital heart defect characterized by a blocked pulmonary valve orifice and elevated right ventricular (RV) pressure, and is often associated with an abnormal connection (fistula) between the RV cavity and a coronary artery (e.g. the left anterior descending artery, LAD). A proximal coronary stenosis is also common and can result in RV-dependent coronary flow, where decompression of the RV by surgical repair of the atresia leads to compromised coronary flow (ischaemia). Using a combined one-dimensional and lumped parameter..

View full abstract