Journal article

Mitochondrial dysfunction in CD4 lymphocytes from stavudine-treated HIV patients

Lloyd Einsiedel, Catherine L Cherry, Freya L Sheeran, Anna Friedhuber, Steve L Wesselingh, Salvatore Pepe

MITOCHONDRION | ELSEVIER SCI LTD | Published : 2010

Abstract

HIV therapy with nucleoside analogue reverse transcriptase inhibitors (NRTI) such as stavudine remains in widespread use in resource-limited nations due to potent efficacy, convenience of formulation and lack of practical alternatives. However, it remains unclear whether adverse side effects with NRTI include reduced mitochondrial respiratory function, particularly in peripheral blood lymphocytes (PBLs). The aim of this study was to determine whether stavudine-based highly active antiretroviral therapy (HAART) is associated with impaired mitochondrial respiratory transport chain function in patient derived CD4+PBLs. CD4+PBLs were isolated from asymptomatic HIV-infected patients treated with ..

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