Decreasing Burden of Malaria in Pregnancy in Malawian Women and Its Relationship to Use of Intermittent Preventive Therapy or Bed Nets
Gaoqian Feng, Julie A Simpson, Ebbie Chaluluka, Malcolm E Molyneux, Stephen J Rogerson
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2010
BACKGROUND: The World Health Organization recommends insecticidal bednets and intermittent preventive treatment to reduce malaria in pregnancy. Longitudinal data of malaria prevalence and pregnancy outcomes are valuable in gauging the impact of these antimalarial interventions. METHODOLOGY/PRINCIPAL FINDINGS: We recruited 8,131 women delivering in a single Malawian hospital over 9 years. We recorded demographic data, antenatal prescription of intermittent preventive therapy during pregnancy with sulfadoxine-pyrimethamine and bed net use, and examined finger-prick blood for malaria parasites and hemoglobin concentration. In 4,712 women, we examined placental blood for malaria parasites and re..View full abstract
Data collection was funded by a Wellcome Trust Senior Research fellowship to SJR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.