A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder
S Dodd, J Kulkarni, L Berk, F Ng, PB Fitzgerald, AR de Castella, S Filia, K Filia, W Montgomery, K Kelin, M Smith, A Brnabic, M Berk
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2010
OBJECTIVES: The clinical significance of subthreshold mixed states is unclear. This study investigated the clinical outcomes in participants with bipolar I disorder or schizoaffective disorder, using the Cassidy and Benazzi criteria for manic and depressive mixed states, respectively. METHODS: Participants (N=239) in a prospective observational study of treatment and outcomes in bipolar I or schizoaffective disorder, bipolar type, were grouped based on study entry clinical presentation as having pure depression (n=63) if they satisfied DSM-IV-TR criteria for a Major Depressive Episode (MDE), depressive mixed state if they also had at least three concurrent hypomanic symptoms (n=33), or not d..View full abstract
This study was supported by funding from Eli Lilly.